Abstract The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR;
however, its function was unknown. Subsequent studies suggest that the MC4R might be …

The melanocortin-4 receptor (MC4R)–embedded in the leptin–melanocortin pathway–is
activated by proopiomelanocortin (POMC)-derived neuropeptides such as α-and β …

The melanogenic actions of the melanocortins are mediated by the melanocortin‐1 receptor
(MC1R). MC1R is a member of the G‐protein‐coupled receptors (GPCR) superfamily …

The melanocortin peptides derived from pro-opiomelanocortin (POMC) were originally
understood in terms of the biological actions of α-melanocyte-stimulating hormone (α-MSH) …

Chromatin endogenous cleavage (ChEC) uses fusion of a protein of interest to micrococcal
nuclease (MNase) to target calcium-dependent cleavage to specific genomic loci in vivo …

Regulation of food intake is a recently identified endocrine function of bone that is mediated
by Lipocalin-2 (LCN2). Osteoblast-secreted LCN2 suppresses appetite and decreases fat …

The peptides α-melanocyte stimulating hormone (α-MSH) and oxytocin, when administered
centrally, produce similar behavioral effects. α-MSH induces Fos expression in supraoptic …

The melanocortin-4 receptor (MC4R) is a member of the rhodopsin-like G protein-coupled
receptor family. The binding of α-MSH to the MC4R leads to increased cAMP production …

The melanocortin (MC) system is probably the best characterized neuropeptide network of
the skin. Most cutaneous cell types express MC receptors (MC-Rs) and synthesize MCs …

The global prevalence of obesity highlights the importance of understanding on regulation of
energy homeostasis. The central melanocortin system is an important intersection …