The ability to measure the properties of proteins at the single-molecule level offers an
unparalleled glimpse into biological systems at the molecular scale. The interpretation of …

Ion channels are characterized by inherently stochastic behavior which can be represented
by continuous-time Markov models (CTMM). Although methods for collecting data from …

In the following we describe a method for calculating sequences of Markov states which are
consistent with both the data I and the model Q. This algorithm was previously used by …