The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in approximately one third of patients
with acute myeloid leukemia (AML), either by internal tandem duplications (FLT3-ITD), or by …

The receptor tyrosine kinase fms-like tyrosine kinase 3 (FLT3), involved in regulating
survival, proliferation, and differentiation of hematopoietic stem/progenitor cells, is …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are often present in newly
diagnosed acute myeloid leukemia (AML) patients with an incidence rate of approximately …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Many cytokines are crucial drivers of cancers and autoimmune conditions. These proteins
bind to receptors and signal their responses through Janus kinase (JAK) and signal …

The presence of FLT3 mutations, including the most common FLT3-ITD (internal tandem
duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable …

Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic
heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has …

Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct
cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics …

Hepatocellular carcinoma (HCC) is a major malignancy that stands second in terms of
global cancer-related mortality. STAT3 has been described as a latent transcription factor …