Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Reactive oxygen species and cell signaling. Review

D Averill-Bates - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2024 - Elsevier
Reactive oxygen species (ROS) is a term encompassing a group of highly reactive oxygen-
derived molecules. In physiological systems, ROS production exists in concert with …

Oxidative stress in cancer cell metabolism

S Arfin, NK Jha, SK Jha, KK Kesari, J Ruokolainen… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

[HTML][HTML] The double-edged roles of ROS in cancer prevention and therapy

Y Wang, H Qi, Y Liu, C Duan, X Liu, T Xia, D Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

G Hoxhaj, BD Manning - Nature Reviews Cancer, 2020 - nature.com
The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Full-coverage regulations of autophagy by ROS: from induction to maturation

J Zhou, XY Li, YJ Liu, J Feng, Y Wu, HM Shen, GD Lu - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is an evolutionarily well-conserved recycling process in
response to stress conditions, including a burst of reactive oxygen species (ROS) …

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

YR Lee, M Chen, PP Pandolfi - Nature reviews Molecular cell biology, 2018 - nature.com
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

ROS signalling in the biology of cancer

JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Reactive oxygen species (ROS) in macrophage activation and function in diabetes

E Rendra, V Riabov, DM Mossel, T Sevastyanova… - Immunobiology, 2019 - Elsevier
In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …