Inter-individual variability in drug response, be it efficacy or safety, is common and likely to
become an increasing problem globally given the growing elderly population requiring …

Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used
globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary …

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is one example of a severe delayed T-cell–mediated adverse …

Background Direct drug provocation test (DPT) without prior skin testing (ST) has been
investigated in children suspected of being at risk for beta-lactam (BL) hypersensitivity …

Drug allergy (DA) remains a complex and unaddressed problem worldwide that often
deprives patients of optimal medication choices and places them at risk for life‐threatening …

Drug hypersensitivity reactions (DHR) are heterogeneous in their pathomechanisms, clinical
presentation, severity, and outcomes. Novel DHR mechanisms, phenotypes, and endotypes …

Although existing as a safety measure to prevent iatrogenic harm, unconfirmed penicillin
allergy labels have a negative impact on personal and public health. One downstream effect …

Introduction: Beta-lactam antibiotics are one of the most common causes of antibiotics-
related severe cutaneous adverse reactions (SCARs) including Stevens–Johnson syndrome …

Beta-lactam antibiotics are the most commonly reported drug allergy in adults and children.
More than 95% of those with reported allergy labels to beta lactams are not confirmed when …