In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy
in adults. Despite the advances made in surgical techniques, radiotherapy and …

Reactive astrocytes have been proposed to become incompetent bystanders in epilepsy as
a result of cellular changes rendering them unable to perform important housekeeping …

Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma,
which result in the accumulation of an “oncometabolite”, D-2-hydroxyglutarate (D-2-HG) …

Background Surgical resection is a universal component of glioma therapy. Little is known
about the postoperative microenvironment due to limited preclinical models. Thus, we …

Resistance to chemotherapeutic drugs remains a great obstacle to successful treatment of
gliomas. Understanding the mechanism of glioma chemoresistance is conducive to develop …

Glioblastoma multiforme (GBM) is the most common and aggressive primary human brain
tumor. Although comprehensive therapies combining radiotherapy and chemotherapy after …

Cancer cell adhesion to the vascular endothelium is an important step in tumor metastasis.
Thy-1 (CD90), a cell adhesion molecule expressed in activated endothelial cells, has been …

Abstract Treatment of glioblastoma (GBM) remains a challenge using conventional
chemotherapy, such as temozolomide (TMZ), and is often ineffective as a result of drug …

Tumour metastasis to the brain is a complex process involving crosstalk between the
circulating tumour cells and the blood brain barrier (BBB). Astrocytes, which reside in the …