Strict regulation of DNA replication is of fundamental significance for the maintenance of
genome stability. Licensing of origins of DNA replication is a critical event for timely genome …

Successful cell proliferation requires efficient and precise genome duplication followed by
accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is …

Understanding protein dynamics is crucial in order to elucidate protein function and
interactions. Advances in modern microscopy facilitate the exploration of the mobility of …

Complete and robust human genome duplication requires loading minichromosome
maintenance (MCM) helicase complexes at many DNA replication origins, an essential …

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to
maintain genome stability. Here we describe our current understanding of the process by …

Eukaryotic replication origins are defined by the ORC‐dependent loading of the Mcm2‐7
helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2‐7 …

Eukaryotic chromosomes contain regions of varying accessibility, yet DNA replication factors
must access all regions. The first replication step is loading MCM complexes to license …

As a crucial component of DNA replication licensing system, minichromosome maintenance
(MCM) 2–7 complex acts as the eukaryotic DNA replicative helicase. The six related MCM …

During late mitosis and the early G1 phase, the origins of replication are licensed by binding
to double hexamers of MCM2–7. In this study, we investigated how licensing and …

The origin of species would not have been possible without high fidelity DNA replication and
complex genomes evolved with mechanisms that control the initiation of DNA replication at …