Evolving a peptide: library platforms and diversification strategies

K Bozovičar, T Bratkovič - International journal of molecular sciences, 2019 - mdpi.com
Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients,
versatile tools in drug discovery, and for drug delivery. They find themselves at the …

RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells

Y Wang, D Chung, LR Monteleone, J Li… - Nucleic Acids …, 2019 - academic.oup.com
Human ADAR3 is a catalytically inactive member of the Adenosine Deaminase Acting on
RNA (ADAR) protein family, whose active members catalyze A-to-I RNA editing in …

Beating Bias in the Directed Evolution of Proteins: Combining High‐Fidelity On‐Chip Solid‐Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial …

A Li, CG Acevedo‐Rocha, Z Sun, T Cox, JL Xu… - …, 2018 - Wiley Online Library
Saturation mutagenesis (SM) constitutes a widely used technique in the directed evolution of
selective enzymes as catalysts in organic chemistry and in the manipulation of metabolic …

Solid‐phase gene synthesis for mutant library construction: the future of directed evolution?

A Li, Z Sun, MT Reetz - ChemBioChem, 2018 - Wiley Online Library
Directed evolution of stereo‐and regioselective enzymes as catalysts in organic chemistry
and biotechnology constitutes a complementary alternative to selective transition‐metal …

Crafting Genetic Diversity: Unlocking the Potential of Protein Evolution

VK Gali, KL Tee, TS Wong - SynBio, 2024 - mdpi.com
Genetic diversity is the foundation of evolutionary resilience, adaptive potential, and the
flourishing vitality of living organisms, serving as the cornerstone for robust ecosystems and …

Innovative techniques for improving microbial enzyme production

A Thakur, C Putatunda, R Sharma, R Mehta… - … interventions and scope, 2020 - Springer
Enzymes are biocatalysts which have a central role in the biochemical, physiological, and
metabolic functioning of all the organisms from micro to macro level. These catalytic proteins …

OverFlap PCR: A reliable approach for generating plasmid DNA libraries containing random sequences without a template bias

A Linars, I Silamikelis, D Gudra, A Roga, D Fridmanis - Plos one, 2022 - journals.plos.org
Over the decades, practical biotechnology researchers have aimed to improve naturally
occurring proteins and create novel ones. It is widely recognized that coupling protein …

[PDF][PDF] Crafting Genetic Diversity: Unlocking the Potential of Protein Evolution. SynBio 2024, 2, 142–173

VK Gali, KL Tee, TS Wong - 2024 - core.ac.uk
Genetic diversity is the foundation of evolutionary resilience, adaptive potential, and the
flourishing vitality of living organisms, serving as the cornerstone for robust ecosystems and …

Analysis of the Impact of MYC Mutant Variants on MYC-Dependent B Cell Lymphomagenesis

J Lee - 2020 - search.proquest.com
Deregulation of the c-MYC (MYC) proto-oncogene drives cancerous transformation. Somatic
missense mutations in its coding sequence are often observed in B cell lymphomas, but the …