Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
Promising antiviral activities of natural flavonoids against SARS-CoV-2 targets: systematic review
The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past …
coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past …
Phase separation in viral infections
H Li, C Ernst, M Kolonko-Adamska… - Trends in …, 2022 - cell.com
Viruses rely on the reprogramming of cellular processes to enable efficient viral replication;
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …
Deconstructing virus condensation
N Lopez, G Camporeale, M Salgueiro… - PLoS …, 2021 - journals.plos.org
Viruses have evolved precise mechanisms for using the cellular physiological pathways for
their perpetuation. These virus-driven biochemical events must be separated in space and …
their perpetuation. These virus-driven biochemical events must be separated in space and …
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
SM Cascarina, ED Ross - Journal of Biological Chemistry, 2022 - ASBMB
In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have
reallocated their time and resources to better our understanding of the virus. For some …
reallocated their time and resources to better our understanding of the virus. For some …
Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein
Worldwide SARS-CoV-2 sequencing efforts track emerging mutations in its spike protein, as
well as characteristic mutations in other viral proteins. Besides their epidemiological …
well as characteristic mutations in other viral proteins. Besides their epidemiological …
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils
E Tayeb-Fligelman, JT Bowler, CE Tai… - Nature …, 2023 - nature.com
The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its
function. Computational analysis of the amino acid sequence of NCAP reveals low …
function. Computational analysis of the amino acid sequence of NCAP reveals low …
Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA–protein condensates
Y Chen, X Lei, Z Jiang, F Humphries… - Proceedings of the …, 2023 - National Acad Sciences
A detailed understanding of the innate immune mechanisms involved in restricting SARS-
CoV-2 infection and how the virus disrupts these processes could reveal new strategies to …
CoV-2 infection and how the virus disrupts these processes could reveal new strategies to …