It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

It is well known that females show a greater susceptibility to alcohol-induced liver injury than
males. Additionally, females who consume alcohol regularly and have been obese for 10 …

PPARγ is required for fat cell development and is the molecular target of antidiabetic
thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal …

Tumor necrosis factor (TNF) α, a pivotal cytokine involved in inflammation, is produced
primarily by Kupffer cells in the liver. It has been shown that inactivation of Kupffer cells …

During the past two decades, studies describing the chemistry and biology of PAF have
been extensive. This potent phosphoacylglycerol exhibits a wide variety of physiological and …

Obesity is commonly associated with development of insulin resistance and systemic
evidence of inflammation. Macrophages contribute to inflammatory amplification in obesity …

An overview of the most important plasma abnormalities that can be found in Gaucher's
disease is presented in this chapter. Attention is focussed on their practical applications and …

The liver is one of the principal organs involved in glucose metabolism together with skeletal
muscle and adipose tissue. A link between diabetes and chronic liver disease (CLD) was …

Why certain individuals are more susceptible than others to harmful effects of chemical
exposure remains incompletely understood. One understudied but potentially important …

Prostanoids are oxygenated metabolites of C20 carboxylic acids, especially arachidonic
acid, and are regarded as modulators of cellular functions in various physiological and …