Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Proteins frequently undergo covalent modification at the post-translational level, which
involves the covalent attachment of chemical groups onto amino acids. This can entail the …

Despite the well-established functions of protein palmitoylation in fundamental cellular
processes, the roles of this reversible post-translational lipid modification in cardiomyocyte …

Cardiac fibrosis is characterized by maladaptive accumulation of collagen and extracellular
matrix (ECM) components in the heart, a condition that decreases cardiac function and …

Cytokine receptors respond to circulating inflammatory cytokines by signaling through Janus
kinases (JAK) to ultimately elicit phosphorylation-dependent nuclear translocation and …

The nonenergy–producing or biomass-accumulating functions of metabolism are attracting
increasing attention, as metabolic changes are gaining importance as discrete signaling …