Circulating plasma proteins play key roles in human health and can potentially be used to
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …

T cells are central players of the adaptive immune system by protecting us from recurring
infections and by killing malignant cells. Protective T cell responses rely on the concerted …

Post-transcriptional regulation is a fundamental process in gene expression that has a role
in diverse cellular processes, including immune responses. A core concept underlying post …

Microeukaryotes are key contributors to marine carbon cycling. Their physiology, ecology,
and interactions with the chemical environment are poorly understood in offshore …

The next steps of deep space exploration are manned missions to Moon and Mars. For safe
space missions for crew members, it is important to understand the impact of space flight on …

Deficiency in human mature frataxin (hFXN-M) protein is responsible for the devastating
neurodegenerative and cardiodegenerative disease of Friedreich's ataxia (FRDA). It results …

During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that
determine their ability to exit quiescence and mount effective immune responses. Here we …

Secreted proteins play critical roles in cellular communication. Methods enabling concurrent
measurement of cellular protein secretion, phenotypes and transcriptomes are still …

Pre‐existing but untranslated or 'poised'mRNA exists as a means to rapidly induce the
production of specific proteins in response to stimuli and as a safeguard to limit the actions …

T cell homeostasis, T cell differentiation, and T cell effector function rely on the constant fine‐
tuning of gene expression. To alter the T cell state, substantial remodeling of the proteome is …