Recent genome sequencing efforts in a variety of cancers have revealed mutations and/or
structural alterations in ATRX and DAXX, which together encode a complex that deposits …

Malignant melanoma is the most deadly form of skin cancer. It originates from melanocytic
cells and can also arise at other body sites. Early diagnosis and appropriate medical care …

Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages.
Although recent progress in biology and treatment has dramatically improved survival rates …

ATRX alterations occur at high frequency in neuroblastoma of adolescents and young
adults. Particularly intriguing are the large N-terminal deletions of ATRX (Alpha …

Melanomas of the skin are poorly circumscribed lesions, very frequently asymptomatic but
unfortunately with a continuous growing incidence. In this landscape, one can distinguish …

Purpose To evaluate targetable mutations and molecular genetic pathways in conjunctival
melanoma with clinical correlation. Design Observational case series. Participants Patients …

ATRX is a chromatin remodeling protein involved in deposition of the histone variant H3. 3 at
telomeres and pericentromeric heterochromatin. It also influences the expression level of …

ATRX was identified over 20 years ago as the gene responsible for a rare developmental
disorder characterized by α-thalassemia and intellectual disability. Similarities to the sucrose …

Background: Survival from melanoma is strongly related to patient sex, with females having
a survival rate almost twice that of males. Many explanations have been proposed but have …

Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a
poor prognosis. However, its genetic basis remains unclear. A series of recent genomic …