Heterotrimeric G protein–coupled receptors (GPCRs) are found on the surface of all cells of
multicellular organisms and are major mediators of intercellular communication. More than …

The assessment of salt sensitivity of blood pressure is difficult because of the lack of
universal consensus on definition. Regardless of the variability in the definition of salt …

Background A silent polymorphism (+ 1166 A/C single-nucleotide polymorphism) localized
in the 3′-UTR (untranslated region) of the human angiotensin II type-1 receptor (AT1R) has …

Traditional behavioral genetic studies (eg, twin, adoption studies) have shown that human
personality has moderate to high heritability, but recent molecular behavioral genetic studies …

Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It
affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion …

Dopamine plays an important role in the pathogenesis of hypertension by regulating
epithelial sodium transport, vascular smooth muscle contractility and production of reactive …

Renalase, a novel flavin adenine dinucleotide-dependent amine oxidase, is secreted by the
kidney, degrades circulating catecholamines, and modulates cardiac function and systemic …

Complex interactions between genes and environment result in a sodium-induced elevation
in blood pressure (salt sensitivity) and/or hypertension that lead to significant morbidity and …

To date, linkage and association studies have not been convincing. Genome-wide
association studies may prove to be an effective approach to the problems posed by …

This review examines the impact of recent discoveries defining personal genetics of
adrenergic signaling polymorphisms on scientific discovery and medical practice related to …