JF Gudernatsch, an anatomist at Cornell Medical School, traveled by ship to the Naples
Zoological Station in the summer of 1910. He took along various mammalian organs …

Metamorphosis, classically defined as a spectacular post-embryonic transition, is well
exemplified by the transformation of a tadpole into a frog. It implies the appearance of new …

Frogs play important ecological roles, and several species are important model organisms
for scientific research. The globally distributed Ranidae (true frogs) are the largest frog …

The timing of metamorphosis is a central amphibian life history trait and is controlled by the
interplay of developmental progression, body size and condition, and environmental signals …

During amphibian metamorphosis, the larval tissues/organs rapidly degenerate to adapt
from the aquatic to the terrestrial life. At the cellular level, a large quantity of apoptosis occurs …

Bisphenol A (BPA), a chemical widely used to manufacture plastics, is estrogenic and
capable of disrupting sex differentiation. However, recent in vitro studies have shown that …

Amphibian metamorphosis perfectly illustrates a key paradox: thyroid hormones control
diverse cellular processes depending on the tissue context. This point is also reinforced by a …

BACKGROUND: Thyroid hormone (TH) receptor (TR) plays critical roles in vertebrate
development. However, the in vivo mechanism of TR action remains poorly explored …

The thyroid hormone receptor TRα1 regulates intestinal development and homeostasis by
controlling epithelial proliferation in the crypts. This involves positive control of the Wnt/β …

The thyroid hormones control the development and the homeostasis of several organs in
vertebrates. Their actions depend, for the most part, on nuclear receptors, the TRs, which are …