Recent advances provide evidence that the cellular signalling pathway comprising the
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …

Heart and kidney failure often co-exist and confer high morbidity and mortality. The complex
bi-directional nature of heart and kidney dysfunction is referred to as cardiorenal syndrome …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Oxygen is a powerful trigger for cellular reactions, but there are few comparative
investigations assessing the effects over a large range of partial pressures. We investigated …

Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein known to be overexpressed
within tumor stroma in several cancer types. While mainly considered as an endogenous …

Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of
senescent compared to normally functioning parenchymal cells increases with age …

Cardiovascular homeostasis and health is maintained through the balanced interactions of
cardiac generated blood flow and cross-talk between the cellular components that comprise …

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies
worldwide, affecting almost 400,000 newborns globally each year. It is characterized by …

Defects in renal tubular epithelial cell repair contribute to renal ischemia reperfusion injury,
cause acute kidney damage, and promote chronic renal disease. The matricellular protein …