Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

Proteins and RNA can phase separate from the aqueous cellular environment to form
subcellular compartments called condensates. This process results in a protein–RNA …

Gasdermin D forms large,~ 21 nm diameter pores in the plasma membrane to drive the cell
death program pyroptosis. These pores are thought to be permanently open, and the …

Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis
involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations …

Phosphoinositides are a family of membrane phospholipids that play crucial roles in
membrane regulatory events. As such, these lipids are often a key part of molecular …

The composition and organization of the plasma membrane play important functional and
regulatory roles in integrin signaling, which direct many physiological and pathological …

Phosphatidylserine (PS) is a critical lipid factor in the assembly and spread of numerous
lipid‐enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix …

Located at the inner leaflet of the plasma membrane (PM), phosphatidyl-inositol 4, 5-
bisphosphate [PI (4, 5) P2] composes only 1–2 mol% of total PM lipids. With its synthesis …

Phospholipid membranes support essential biochemical processes, yet remain difficult to
characterize due to their compositional and structural heterogeneity. The two most common …