This review article summarizes the recent advances in pathogenic mechanisms and novel
therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and …

Biofilms associated with the human body, particularly in typically sterile locations, are difficult
to diagnose and treat effectively because of their recalcitrance to conventional antibiotic …

Background: Next-generation sequencing is a well-established technique for sequencing of
DNA and has recently gained attention in many fields of medicine. Our aim was to evaluate …

Background. The value of microbiological culture to diagnose late periprosthetic infection is
limited, especially because standard methods may fail to detect biofilm-forming sessile or …

Although prosthetic joint infection (PJI) is a rare event after arthroplasty, it represents a
significant complication that is associated with high morbidity, need for complex treatment …

The role of Propionibacterium acnes in acne and in a wide range of inflammatory diseases
is well established. However, P. acnes is also responsible for infections involving implants …

The generation of wear debris is an inevitable result of normal usage of joint replacements.
Wear debris particles stimulate local and systemic biological reactions resulting in chronic …

Prosthesis-related infection is a serious complication for patients after orthopedic joint
replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most …

Propionibacterium acnes colonizes the lipid-rich sebaceous glands of the skin. This
preferential anaerobic bacterium is easily identified if cultures are prolonged. It is involved in …

Implanted devices are mainly used to improve impaired function or to replace missing
anatomic structures. They are made of synthetic material or devitalized biological structures …