Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

In recent years, increasing attention has been paid to the pharmacological efficacy of
tannins. Tannic acid (TA), the simplest hydrolysable tannin that has been approved by the …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound
healing response to repeated or chronic tissue injury, and may lead to the disruption of …

Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Fibrosis–a debilitating condition that can occur in most organs–is characterized by excess
deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of …

Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic …

Pulmonary fibrosis (PF) is characterized by aberrant extracellular matrix (ECM) deposition,
activation of fibroblasts to myofibroblasts and parenchymal disorganization, which have an …