Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of cirrhosis and/or
porto-systemic shunting. The clinical symptoms are widely variable, extending from subtle …

Hepatic encephalopathy (HE) may occur in patients with liver failure. The most critical
pathophysiologic mechanism of HE is cerebral edema following systemic hyperammonemia …

The biological nitrogen cycle involves step-wise reduction of nitrogen oxides to ammonium
salts and oxidation of ammonia back to nitrites and nitrates by plants and bacteria. Neither …

Background & Aims Increased plasma ammonia concentration and consequent disruption of
brain energy metabolism could underpin the pathogenesis of hepatic encephalopathy (HE) …

Hepatic encephalopathy (HE) is a serious neuropsychiatric complication that occurs as a
result of liver failure. Umbelliferone (UMB; 7-hydroxycoumarin) is a natural product with …

The NO-cGMP signal transduction pathway plays a crucial role in tone regulation in hepatic
sinusoids and peripheral blood vessels. In a cirrhotic liver, the key enzymes endothelial NO …

Infections are common among patients with liver cirrhosis. They occur more often in cirrhotic
patient groups than in the general population and result in higher mortality. One reason for …

Hyperammonemia is the pathological accumulation of ammonia in the blood, which can
occur in many different clinical settings. Most commonly in adults, hyperammonemia occurs …

Since 1976, more and more PET radiopharmaceuticals have been developed as the clinical
introduction of [18F] FDG for various medical applications. However, few of them could be …

Sepsis-Associated Encephalopathy (SAE) is a common complication in the acute phase of
sepsis, and patients who develop SAE have a higher mortality rate, longer hospital stay, and …