Current applications of Suzuki–Miyaura coupling reaction in the total synthesis of natural products: an update

A Taheri Kal Koshvandi, MM Heravi… - Applied …, 2018 - Wiley Online Library
Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis
of natural products. We underscored these achievements in a report published in …

The molecular industrial revolution: automated synthesis of small molecules

M Trobe, MD Burke - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Today we are poised for a transition from the highly customized crafting of specific molecular
targets by hand to the increasingly general and automated assembly of different types of …

Towards the generalized iterative synthesis of small molecules

JW Lehmann, DJ Blair, MD Burke - Nature Reviews Chemistry, 2018 - nature.com
Small molecules have extensive untapped potential to benefit society, but access to this
potential is too often restricted by limitations inherent to the highly customized approach that …

Recent advances in the synthesis and reactivity of MIDA boronates

D Aich, P Kumar, D Ghorai, KK Das… - Chemical …, 2022 - pubs.rsc.org
Organoboron compounds have a wide-range of applications in synthetic methodologies,
natural products, and bioactive molecule synthesis. The sensitivity of boronic acid toward …

Sequential and iterative Pd-catalyzed cross-coupling reactions in organic synthesis

P Dobrounig, M Trobe, R Breinbauer - Monatshefte für Chemie-Chemical …, 2017 - Springer
Sequential and iterative Pd-catalyzed cross-coupling reactions can be performed in which
the order of C–C bond formations can be controlled either by the attenuated leaving groups …

Peridinin is an exceptionally potent and membrane-embedded inhibitor of bilayer lipid peroxidation

HMS Haley, AG Hill, AI Greenwood… - Journal of the …, 2018 - ACS Publications
Antilipoperoxidant protein dysfunction is associated with many human diseases, suggesting
that bilayer lipid peroxidation may contribute broadly to pathogenesis. Small molecule …

Stereoselective Bromoboration of Acetylene with Boron Tribromide: Preparation and Cross-Coupling Reactions of (Z)-Bromovinylboronates

J Polášek, J Paciorek, J Stošek… - The Journal of …, 2020 - ACS Publications
The mechanism of acetylene bromoboration in neat boron tribromide was studied carefully
by means of experiment and theory. Besides the syn-addition mechanism through a four …

Modular syntheses of phenanthroindolizidine natural products

YI Jo, MD Burke, CH Cheon - Organic letters, 2019 - ACS Publications
A highly concise strategy for the total synthesis of phenanthroindolizidines was developed.
The one-pot iterative Suzuki–Miyaura reaction of aryl boronic acids with ortho-bromoaryl N …

Die molekulare industrielle Revolution: zur automatisierten Synthese organischer Verbindungen

M Trobe, MD Burke - Angewandte Chemie, 2018 - Wiley Online Library
Derzeit kündigt sich ein Wandel von der manuellen Synthese spezifischer Moleküle, die
über individuell angepasste Routen verläuft, hin zu automatisch zusammenfügten …

Total Synthesis of (−)-Lamellodysidine A via an Intramolecular Diels–Alder Reaction

S Kamo, H Kurosawa, A Matsuzawa, K Sugita - Organic Letters, 2022 - ACS Publications
In this study, we achieved an eight-step enantioselective synthesis of (−)-lamellodysidine A,
a structurally intriguing sesquiterpene natural product featuring a 5/5/6/6-fused tetracyclic …