Highlights•Complex regulatory interactions ensure female-specific monoallelic Xist
expression.•Stochastic upregulation combined with a negative feedback can explain the Xist …

Abstract Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin,
is progressively implemented during development to contribute to cell fate restriction as …

Long non-coding RNAs (lncRNA) comprise a diverse group of non-protein-coding RNAs>
200 bp in length that are involved in various normal cellular processes and disease states …

Cis-natural antisense transcripts (cis-NATs) are transcribed from the same genomic locus as
their partner gene but from the opposite DNA strand and overlap with the partner gene …

The process of epigenetic silencing, while fundamentally important, is not yet completely
understood. Here we report a replenishable female mouse embryonic stem cell (mESC) …

Epigenetic modifications to DNA are crucial for normal cellular and biological functioning.
DNA methylation, histone modifications, and chromatin remodeling are the most common …

Compensation for the gene dosage disequilibrium between sex chromosomes in mammals
is achieved in female cells by repressing one of its X chromosomes through a process called …

Background Sex disparities constitute a significant issue in hepatocellular carcinoma (HCC).
However, the mechanism of gender dimorphism in HCC is still not completely understood …

This Review elucidates the regulatory principles of random monoallelic expression by
focusing on two well-studied examples: the X-chromosome inactivation regulator Xist and …

The capacity of cells to retain a memory of previous signals enables them to adopt unique
cell fates and adjust to their surrounding environment. The underlying gene expression …