T follicular helper cell biology: a decade of discovery and diseases
S Crotty - Immunity, 2019 - cell.com
Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
Cytokine-skewed Tfh cells: functional consequences for B cell help
AC Olatunde, JS Hale, TJ Lamb - Trends in immunology, 2021 - cell.com
CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
Identification of a T follicular helper cell subset that drives anaphylactic IgE
INTRODUCTION Cross-linking of high-affinity, allergen-specific immunoglobulin E (IgE) on
mast cells results in anaphylaxis, a potentially life-threatening allergic reaction. The cellular …
mast cells results in anaphylaxis, a potentially life-threatening allergic reaction. The cellular …
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
A Kendirli, C de la Rosa, KF Lämmle, K Eglseer… - Nature …, 2023 - nature.com
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …
lack a comprehensive understanding of the signaling pathways that regulate this process …
Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH)
Follicular helper T cells (T FH) are essential B cell-help providers in the formation of
germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity …
germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity …
[HTML][HTML] PD-1hiCXCR5–T peripheral helper cells promote B cell responses in lupus via MAF and IL-21
AV Bocharnikov, J Keegan, VS Wacleche, Y Cao… - JCI insight, 2019 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …
CD4+ T cells that help B cells–a proposal for uniform nomenclature
T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in
secondary lymphoid tissues.'Tfh-like'populations not expressing the canonical Tfh cell …
secondary lymphoid tissues.'Tfh-like'populations not expressing the canonical Tfh cell …
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in
diagnosis for decades. However, the immunological mechanism underlying their generation …
diagnosis for decades. However, the immunological mechanism underlying their generation …
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits
T follicular helper (TFH) cells are a distinct type of CD4+ T cells that are essential for most
antibody and B lymphocyte responses. TFH cell regulation and dysregulation is involved in …
antibody and B lymphocyte responses. TFH cell regulation and dysregulation is involved in …
The transcription factor Mef2d regulates B:T synapse–dependent GC-TFH differentiation and IL-21–mediated humoral immunity
Communication between CD4 T cells and cognate B cells is key for the former to fully mature
into germinal center–T follicular helper (GC-TFH) cells and for the latter to mount a CD4 T …
into germinal center–T follicular helper (GC-TFH) cells and for the latter to mount a CD4 T …