Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (radical dot NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO
synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by …

Systemic arterial hypertension is a highly prevalent cardiovascular risk factor that causes
significant morbidity and mortality, and is becoming an increasingly common health problem …

Endothelial dysfunction in the setting of cardiovascular risk factors such as
hypercholesterolemia, diabetes mellitus, chronic smoking, as well hypertension, is, at least …

Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and
considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase …

Objective: To investigate the influence of common and low-frequency genetic variants on the
risk of ischemic stroke (all IS) and etiologic stroke subtypes. Methods: We meta-analyzed 12 …

In the vasculature, reactive oxidant species, including reactive oxygen, nitrogen, or
halogenating species, and thiyl, tyrosyl, or protein radicals may oxidatively modify lipids and …

Significance: Hypertension has major health consequences, which is associated with
endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide (NO) …

Nitric oxide (NO), a key regulator of cardiovascular function, is synthesized from L-arginine
and oxygen by the enzyme nitric oxide synthase (NOS). This reaction requires …

l‐A rginine (l‐A rg) is a conditionally essential amino acid in the human diet. The most
common dietary sources of l‐A rg are meat, poultry and fish. l‐A rg is the precursor for the …