Background Prediction of radiobiological response is a major challenge in radiotherapy. Of
several radiobiological models, the linear-quadratic (LQ) model has been best validated by …

Radiation is an important component of cancer treatment with more than half of all patients
receive radiotherapy during their cancer experience. While the impact of radiation on tumour …

Background Prostate cancer might have high radiation-fraction sensitivity that would give a
therapeutic advantage to hypofractionated treatment. We present a pre-planned analysis of …

Purpose Men with localized prostate cancer often are treated with external radiotherapy (RT)
over 8 to 9 weeks. Hypofractionated RT is given over a shorter time with larger doses per …

The biological effectiveness of proton beams relative to photon beams in radiation therapy
has been taken to be 1.1 throughout the history of proton therapy. While potentially …

Background Studies have reported a low α/β ratio for prostate cancer, suggesting that
hypofractionation could enhance the biological tumour dose without increasing …

Purpose The aim of this guideline is to present recommendations regarding moderately
hypofractionated (240-340 cGy per fraction) and ultrahypofractionated (500 cGy or more per …

Purpose To determine if escalated radiation dose using hypofractionation significantly
reduces biochemical and/or clinical disease failure (BCDF) in men treated primarily for …

Background External beam radiation therapy (EBRT) is a standard definitive treatment
option for men with localized prostate cancer and confers long-term prostate cancer control …

Background and purpose Local recurrences after radiotherapy for prostate cancer (PCa)
often originate at the location of the macroscopic tumour (s). Since PCa cells are known to …