Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

Bioorthogonal reactions have found widespread use in applications ranging from glycan
engineering to in vivo imaging. Researchers have devised numerous reactions that can be …

Recently, click chemistry has provided important advances in biomedical research fields.
Particularly, copper-free click chemistry including strain-promoted azide–alkyne …

Bioorthogonal pretargeting optical imaging shows the potential for enhanced diagnosis and
prognosis. However, the bioorthogonal handles, known for being “always reactive”, may …

Radiotheranostics, injectable radiopharmaceuticals with antitumour effects, have seen rapid
development over the past decade. Although some formulations are already approved for …

This review focuses on the smart chemistry that has been utilized in developing polymer-
based drug delivery systems over the past 10 years. We provide a comprehensive overview …

Bioorthogonal catalysis broadens the functional possibilities of intracellular chemistry.
Effective delivery and regulation of synthetic catalytic systems in cells are challenging due to …