Role of polyphenols in combating Type 2 Diabetes and insulin resistance

M Shahwan, F Alhumaydhi, GM Ashraf… - International journal of …, 2022 - Elsevier
Compromised carbohydrate metabolism leading to hyperglycemia is the primary metabolic
disorder of non-insulin-dependent diabetes mellitus. Reformed digestion and altered …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Dietary polyphenols as antidiabetic agents: Advances and opportunities

C Sun, C Zhao, EC Guven, P Paoli… - Food …, 2020 - Wiley Online Library
Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals,
human study, and clinical trial. The number of publication (Indexed by Web of Science) on …

Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Strategies to increase nitric oxide signalling in cardiovascular disease

JO Lundberg, MT Gladwin, E Weitzberg - Nature reviews Drug …, 2015 - nature.com
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Polyphenol health effects on cardiovascular and neurodegenerative disorders: a review and meta-analysis

F Potì, D Santi, G Spaggiari, F Zimetti… - International journal of …, 2019 - mdpi.com
Several studies have demonstrated that polyphenol-enriched diets may have beneficial
effects against the development of degenerative diseases, including atherosclerosis and …

Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

D Del Rio, A Rodriguez-Mateos… - Antioxidants & redox …, 2013 - liebertpub.com
Human intervention trials have provided evidence for protective effects of various (poly)
phenol-rich foods against chronic disease, including cardiovascular disease …

Dietary polyphenols and type 2 diabetes: Human Study and Clinical Trial

H Cao, J Ou, L Chen, Y Zhang… - Critical reviews in …, 2019 - Taylor & Francis
Significant evidence from epidemiological investigations showed that dietary polyphenols
might manage and prevent type 2 diabetes (T2D). This review summarizes human studies …

Dietary polyphenols and type 2 diabetes: current insights and future perspectives

JB Xiao, P Hogger - Current medicinal chemistry, 2015 - ingentaconnect.com
Significant evidence suggests that polyphenol-rich diets have the ability to protect against
diabetes. Since several previous reviews focused on the nutrition and health effects …

[HTML][HTML] Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

L Hooper, C Kay, A Abdelhamid, PA Kroon… - The American journal of …, 2012 - Elsevier
Background: There is substantial interest in chocolate and flavan-3-ols for the prevention of
cardiovascular disease (CVD). Objective: The objective was to systematically review the …