Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

M Chilosi, A Carloni, A Rossi, V Poletti - Translational Research, 2013 - Elsevier
Different anatomic and physiological changes occur in the lung of aging people that can
affect pulmonary functions, and different pulmonary diseases, including deadly diseases …

Mesenchymal stem cell‐based therapy for kidney disease: a review of clinical evidence

AJ Peired, A Sisti, P Romagnani - Stem cells international, 2016 - Wiley Online Library
Mesenchymal stem cells form a population of self‐renewing, multipotent cells that can be
isolated from several tissues. Multiple preclinical studies have demonstrated that the …

Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic …

FF Cruz, ZD Borg, M Goodwin… - Stem cells …, 2015 - academic.oup.com
An increasing number of studies demonstrate that administration of either conditioned media
(CM) or extracellular vesicles (EVs) released by mesenchymal stromal cells (MSCs) derived …

Mesenchymal stromal cells anno 2019: dawn of the therapeutic era? Concise review

MJ Hoogduijn, E Lombardo - Stem cells translational medicine, 2019 - academic.oup.com
Summary 2018 was the year of the first marketing authorization of an allogeneic stem cell
therapy by the European Medicines Agency. The authorization concerns the use of …

[HTML][HTML] The role of CD4+ FoxP3+ regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment

Y Wang, J Zheng, MS Islam, Y Yang… - International journal of …, 2021 - ncbi.nlm.nih.gov
The severe cases of Coronavirus Disease 2019 (COVID-19) frequently exhibit excessive
inflammatory responses, acute respiratory distress syndrome (ARDS), coagulopathy, and …

Regulatory T cells and acute lung injury: cytokines, uncontrolled inflammation, and therapeutic implications

S Lin, H Wu, C Wang, Z Xiao, F Xu - Frontiers in immunology, 2018 - frontiersin.org
Acute respiratory distress syndrome/acute lung injury (ALI) was described in 1967. The
uncontrolled inflammation is a central issue of the syndrome. The regulatory T cells (Tregs) …

Concise review: mesenchymal stem (stromal) cells: biology and preclinical evidence for therapeutic potential for organ dysfunction following trauma or sepsis

MA Matthay, S Pati, JW Lee - Stem Cells, 2017 - academic.oup.com
Several experimental studies have provided evidence that bone-marrow derived
mesenchymal stem (stromal) cells (MSC) may be effective in treating critically ill surgical …

Regulatory T cells (Tregs) and COVID-19: unveiling the mechanisms, and therapeutic potentialities with a special focus on long COVID

M Dhawan, AA Rabaan, S Alwarthan, M Alhajri… - Vaccines, 2023 - mdpi.com
The COVID-19 pandemic has caused havoc all around the world. The causative agent of
COVID-19 is the novel form of the coronavirus (CoV) named SARS-CoV-2, which results in …

Aging mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response

ML Bustos, L Huleihel, MG Kapetanaki… - American journal of …, 2014 - atsjournals.org
Rationale: Aging is characterized by functional impairment and reduced capacity to respond
appropriately to environmental stimuli and injury. With age, there is an increase in the …

In vivo effects of mesenchymal stromal cells in two patients with severe acute respiratory distress syndrome

OE Simonson, D Mougiakakos… - Stem cells …, 2015 - academic.oup.com
Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various
inflammatory diseases because of their immunomodulatory and reparative properties …