Follicular development is a critical process in reproductive biology that determines the
number of oocytes and interacts with various cells within the follicle (such as oocytes …

The ovarian cortical reserve of follicles is vital for fertility. Some medical treatments are toxic
to follicles, leading to premature ovarian insufficiency. Ovarian tissue cryopreservation is an …

The reproductive and endocrine functions of the ovary involve spatially defined interactions
among specialized cell populations. Despite the ovary's importance in fertility and endocrine …

The process of mammalian reproduction involves the development of fertile germ cells in the
testis and ovary, supported by the surrounders. Fertilization leads to embryo development …

Introduction Granulosa cells (GCs) and theca cells (TCs) play a pivotal role in human
ovarian steroidogenesis, facilitating the conversion of cholesterol into sex steroids that …

The heterogeneity of ovarian mesenchymal/stromal cells has just been revealed in both
mice and humans. However, it remains unclear about the cellular development trace and the …

Background The objective of this study was to induce the differentiation of human theca stem
cells (hTSCs) into germ cell-like cells (hGCLCs) and assess their developmental …

STUDY QUESTION Can secondary follicles be obtained from cultured cryopreserved-
thawed human ovarian cortical tissue? SUMMARY ANSWER We obtained high-quality …

The ovary plays a crucial role in the reproductive system of female mammals by producing
mature oocytes through folliculogenesis. Non-human model organisms are extensively …

Background Classic galactosemia (CG) is an inborn error of galactose metabolism caused
by mutations in the GALT gene. Premature ovarian insufficiency (POI) is a later complication …