Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

During the past few years studies from several laboratories have utilized gene disruption
approaches to define the function of members of the Stat family of transcription factors. The …

Aberrant activation of the JAK/STAT pathway has been reported in a variety of disease
states, including inflammatory conditions, hematologic malignancies, and solid tumors. For …

▪ Abstract Cytokines are an integral component of the adaptive and innate immune
responses. The signaling pathways triggered by the engagement of cytokines with their …

Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …

Polycythemia vera (PV) is a human clonal hematological disorder. The molecular etiology of
the disease has not been identified. PV hematopoietic progenitor cells exhibit …

The regulation of tyrosine phosphorylation and associated signalling through antigen,
growth-factor and cytokine receptors is mediated by the reciprocal activities of protein …

Upon interferon (IFN) stimulation, Stat1 becomes tyrosine phosphorylated and translocates
into the nucleus, where it binds to DNA to activate transcription. The activity of Stat1 is …

Recent advances in our understanding of the pathogenesis of the Philadelphia chromosome-
negative myeloproliferative neoplasms, polycythaemia vera, essential thrombocythaemia …

Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this
systematic analysis of lymph gland structure and gene expression, we define the …