Biocatalysis has found numerous applications in various fields as an alternative to chemical
catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for …

Die Biokatalyse hat in verschiedenen Einsatzgebieten Anwendung als Alternative zur
chemischen Katalyse gefunden, wobei die herausragendsten Beispiele die Herstellung …

Transaminases are attractive catalysts for the production of enantiopure amines. However,
the poor stability of these enzymes often limits their application in biocatalysis. Here, we …

An amine transaminase was engineered for the efficient production of a chiral precursor to
sacubitril,(2 R, 4 S)-5-([1, 1′-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid, a key …

Amine transaminases (ATAs) propose an appealing alternative to transition metal catalysts
as they can provide chiral amines of high purity from pro-chiral compounds by asymmetric …

A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from
alkynes was developed. In this integrated approach, just ppm amounts of gold catalysts …

Abstract ω‐Transaminases (ω‐TAs) show considerable potential for the synthesis of chiral
amines. However, their low catalytic efficiency towards bulky substrates limits their …

Furfurylamine is recognized as an attractive platform molecule for production of fibers,
perfumes, additives, medicines and agrochemicals. It can be synthesized from …

Amine transaminase catalyzed reaction systems allow the efficient production of high value
active pharmaceutical ingredients via stereoselective amination of prochiral precursors …

Amine transaminases are frequently used for the production of chiral amines starting from
prochiral ketones. These amines can be applied as active pharmaceutical ingredients or …