Now that enzymes are available that are stable above 100° C it is possible to investigate
conformational stability at this temperature, and also the effect of high-temperature …

Deamidated, isomerized, and racemized aspartyl and asparaginyl residues represent a
significant part of the spontaneous damage to proteins that results from the aging process …

Formation of β-linked Asp-Xaa peptide bonds–isoaspartyl (isoAsp) sites–arise in proteins
via succinimide− linked deamidation of asparagine or dehydration of aspartate, reactions …

A 1,288±271‐yr‐old (1,350±220 yr BP, radiocarbon age) seed of Sacred Lotus (Nelumbo
nucifera Gaertn.) from an ancient lake bed at Pulantien, Liaoning Province, China, has been …

Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in
charge and conformation of peptides and proteins. Quantitative and experimentally verified …

l-Asparaginyl and l-aspartyl residues in proteins are subject to spontaneous degradation
reactions that generate isomerized and racemized aspartyl derivatives. Proteins containing l …

A method for the quantitative estimation of instability with respect to deamidation of the
asparaginyl (Asn) residues in proteins is described. The procedure involves the observation …

Comprehensive multidisciplinary encyclopedia dealing with aging processes and older
adults. Intended for" the educated inquirer who needs a brief authoritative introduction to key …

We reviewed here that protein isomerization is enhanced in amyloid-β peptides (Aβ) and
paired helical filaments (PHFs) purified from Alzheimer's disease (AD) brains. Biochemical …

The normal functioning immune system is programmed to attack foreign pathogens and
other foreign proteins while maintaining tolerance to self-proteins. The mechanisms by …