The growing prevalence of metabolic syndrome (MetS) in the US and even worldwide is
becoming a serious health problem and economic burden. MetS has become a crucial risk …

The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …

Background & Aims Transmembrane protein 173 (TMEM173 or STING) signaling by
macrophage activates the type I interferon-mediated innate immune response. The innate …

Background: Obesity is one of the leading causes of preventable death worldwide.
Circadian rhythms are known to control both sleep timing and energy homeostasis, and …

It has been appreciated for many years that there is a strong association between
metabolism and immunity in advanced metazoan organisms. Distinct immune signatures …

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose
tissue dysfunction and contributing to obesity-induced inflammation and metabolic …

The mammalian circadian clock relies on the transcription factor CLOCK: BMAL1 to
coordinate the rhythmic expression of 15% of the transcriptome and control the daily …

The circadian clock is an endogenous timekeeper system that controls and optimizes
biological processes, which are consistent with a master circadian clock and peripheral …

Although obesity is considered to result from an imbalance between energy uptake and
energy expenditure, the strategy of dietary changes and physical exercise has failed to …

One of the pathologic hallmarks of obesity is macrophage infiltration of adipose tissue that
has been confirmed as source of multipotent adult stem cells. Stem cell growth factor-beta …