Synthetic organic chemistry is based on the concourse of reagents and catalysts to achieve
the clean formation of new bonds, and appropriate protecting groups are required to prevent …

Peptide nucleic acids (PNAs) are an important class of DNA/RNA mimics that can hybridize
complementary chains of nucleic acids with high affinity and specificity. Because of this …

The activation of carboxylic acids for the formation of amides or esters is an important
process usually carried out using the so-called peptide coupling reagents.'The formation of …

For the controlled synthesis of even the simplest dipeptide, the Nα‐amino group of one of
the amino acids and the C‐terminal carboxyl group of the other should both be blocked with …

Over the last three decades the importance of organosilicon chemistry has greatly increased
because it has opened a number of new synthetic strategies. Silicon reagents are usually …

The reader is first directed to Part I of this Perspective, 1 in which the originators of many gel-
type matrixes have described the development of their materials. In Part II, the story …

Recent discovery of potent antibacterial antisense PNA-peptide conjugates encouraged
development of a fast and efficient synthesis protocol that facilitates structure-activity studies …

Peptide nucleic acids (PNAs) hybridize to natural oligonucleotides according to Watson and
Crick base‐pairing rules. The robustness of PNA oligomers and ease of synthesis have …

A practical and efficient method for PNA synthesis using an azide group to mask the N-
terminus is reported. The deprotection was carried out in 5 min, while couplings were …

Background: Open Access Perspective Reflections on a Copenhagen–Minneapolis Axis in
Bioorganic Chemistry by George Barany 1,* and Paul R. Hansen 2 1 Department of …