G protein-coupled receptors (GPCRs) are important regulators of various cellular functions
via activation of intracellular signaling events. Active GPCR signaling is shut down by GPCR …

GRK2 is a ubiquitous member of the G protein‐coupled receptor kinase (GRK) family that
appears to play a central, integrative role in signal transduction cascades. GRKs participate …

The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation
and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological …

While cardiac hypertrophy elicited by pathological stimuli eventually leads to cardiac
dysfunction, exercise‐induced hypertrophy does not. This suggests that a beneficial …

Myocardial protection against ischemia/reperfusion injury (IRI) is mediated by various
ligands, activating different cellular signaling cascades. These include classical cytosolic …

Heterotrimeric guanine nucleotide-binding (G) protein-coupled receptor kinases (GRKs) are
cytosolic proteins that are known to contribute to the adaptation of the heptahelical G protein …

Studies from our lab have shown that decreasing myocardial G protein–coupled receptor
kinase 2 (GRK2) activity and expression can prevent heart failure progression after …

The ubiquitin-proteasome system (UPS) plays a central role in protein degradation and
regulates a variety of critical cellular processes. During recent years, the cardiac UPS has …

Regulatory single nucleotide polymorphisms (rSNPs) which change the transcriptional factor
binding sites (TFBS) for transcriptional factors (TFs) to bind DNA were reviewed for the …

Cardiac fibroblasts (CF) play a critical role in post-infarction remodeling which can ultimately
lead to pathological fibrosis and heart failure. Recent evidence demonstrates that remote …