YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

Transcriptional enhanced associate domain (TEAD) transcription factors play important roles
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …

Pancreatic cancer is often detected late, when curative therapies are no longer possible.
Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5 …

Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …

As it is closely associated with tumor proliferation, metastasis, and the immunosuppressive
microenvironment, the dysfunctional Hippo pathway has become an extremely attractive …

Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration.
Dysregulation of the Hippo pathway has been recognized in a variety of human cancers …

Mitochondria are key regulators of cell fate through controlling ATP generation and
releasing pro-apoptotic factors. Cardiac ischemia/reperfusion (I/R) injury to the coronary …

Simple Summary Obesity is recognized as a chronic progressive disease and risk factor for
many human diseases. The high and increasing number of obese people may underlie the …

Pancreatic cancer is one of the most devastating cancers with poor prognosis and no
significant change in the survival rate over the past decades. Localized targeted drug …

Yes‑associated protein (YAP) acts as a transcriptional co‑activator in gene expression and
cell proliferation control by binding to the transcriptional factor TEA domain (TEAD) of the …