The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Cryo-EM structures of the active NLRP3 inflammasome disc
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
How location and cellular signaling combine to activate the NLRP3 inflammasome
A Akbal, A Dernst, M Lovotti, MSJ Mangan… - Cellular & molecular …, 2022 - nature.com
Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
Pharmacological inhibition of the NLRP3 inflammasome: structure, molecular activation, and inhibitor-NLRP3 interaction
Q Ma, J Schuetz - Pharmacological reviews, 2023 - Elsevier
The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
The NLRP3 inflammasome: an overview of mechanisms of activation and regulation
N Kelley, D Jeltema, Y Duan, Y He - International journal of molecular …, 2019 - mdpi.com
The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
Summary The NACHT-, leucine-rich-repeat-(LRR), and pyrin domain-containing protein 3
(NLRP3) is emerging to be a critical intracellular inflammasome sensor of membrane …
(NLRP3) is emerging to be a critical intracellular inflammasome sensor of membrane …
Signaling pathways of chronic kidney diseases, implications for therapeutics
Q Yuan, B Tang, C Zhang - Signal transduction and targeted therapy, 2022 - nature.com
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
The NLRP3 inflammasome: Mechanism of action, role in disease and therapies
L Wang, AV Hauenstein - Molecular aspects of medicine, 2020 - Elsevier
NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …