Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

For the past three decades, the use of genomics to inform drug discovery and development
pipelines has generated both excitement and scepticism. Although earlier efforts …

Background Sepsis is a leading cause of childhood mortality worldwide. We assessed
population-based incidence and outcomes of blood culture-proven bacterial sepsis in …

Purpose The definitions of sepsis and septic shock have recently been revised in adults, but
contemporary data are needed to inform similar approaches in children. Methods …

Computational analyses of human patient exomes aim to filter out as many nonpathogenic
genetic variants (NPVs) as possible, without removing the true disease-causing mutations …

Background Sepsis is a heterogeneous disease, therefore the single-gene-based biomarker
is not sufficient to fully understand the disease. Higher-level biomarkers need to be explored …

Recent studies have demonstrated distinct epidemiological patterns pertinent to age groups,
healthcare settings, and comorbidities in the era post meningococcal epidemics. Although …

Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic
changes play a key role in the immune response to bacteria, among which DNA …

Pseudomonas aeruginosa (PA), a nonlactose fermenting gram-negative bacillus, is a
common cause of nosocomial infections in critically ill or debilitated patients, particularly …

Macrophage migration inhibitory factor (MIF) is a pleiotropic, constitutively expressed, pro-
inflammatory cytokine and an important regulator of immune responses. d-dopachrome …