Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

Chemokines facilitate leukocyte migration and positioning as well as other processes such
as angiogenesis and leukocyte degranulation. The burgeoning knowledge on chemokines …

We investigated the capacity of human islets to produce monocyte chemoattractant protein-1
(MCP-1). Primary cultures of pancreatic islets expressed and secreted MCP-1, as …

Review discusses the role of CXCL12 (SDF1α) as a regulatory chemokine that drives Foxp3-
regulatory T cells (Tr1), and its therapeutic implications. Chemokines are a group of small …

Invariant CD1D-restricted natural killer T (iNKT) cells function during innate and adaptive
immunity and regulate numerous immune responses, such as autoimmune disease, tumour …

Anthraquinones are a class of aromatic compounds with a 9, 10‐dioxoanthracene core. So
far, 79 naturally occurring anthraquinones have been identified which include emodin …

Human T2D is characterized by a low-grade systemic inflammation, loss of β-cells, and
diminished insulin production. Local islet immunity is still poorly understood, and hence, we …

Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from
chronic and progressive destruction of pancreatic beta-cells by the immune system. The …

More than one-half of the~ 50 human chemokines have been associated with or implicated
in the pathogenesis of type 1 diabetes, yet their actual expression patterns in the islet …

Growing evidence indicates that structural cells play a crucial role in the chronic
inflammation of autoimmunity by their recruitment of chemokine-dependent cells. Members …