[2+ 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses

P Yang, Q Jia, S Song, X Huang - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to the end of 2021 [2+ 2]-Type cyclobutane natural products are
biosynthetically derived from intermolecular [2+ 2] cycloaddition or intramolecular [2+ 2] …

Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants

Z Hu, X Liu, M Tian, Y Ma, B Jin, W Gao… - Medicinal Research …, 2021 - Wiley Online Library
Abstract Diterpenoids, including more than 18,000 compounds, represent an important class
of metabolites that encompass both phytohormones and some industrially relevant …

Allylic hydroxylation of enones useful for the functionalization of relevant drugs and natural products

CY Zheng, JM Yue - Nature Communications, 2023 - nature.com
Enones are privileged structural motifs in bioactive natural products and pharmaceuticals,
but the γ-hydroxylation of enones is challenging. Here we show a mild and efficient method …

Tetracyclic diterpenoid synthesis facilitated by ODI-cascade approaches to bicyclo [3.2. 1] octane skeletons

K Gao, J Hu, H Ding - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Tetracyclic diterpenoids (C20) mainly refer to the plant terpenoids bearing
biogenetically related carbon skeletons derived from copalyl diphosphates (ent-CPP and …

Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase

Y Tong, X Ma, T Hu, K Chen, G Cui, P Su… - Plant Biotechnology …, 2023 - Wiley Online Library
Selaginella moellendorffii miltiradiene synthase (Sm MDS) is a unique bifunctional
diterpene synthase (diTPS) that catalyses the successive cyclization of (E, E, E) …

Diterpenes specially produced by fungi: Structures, biological activities, and biosynthesis (2010–2020)

FL Zhang, T Feng - Journal of Fungi, 2022 - mdpi.com
Fungi have traditionally been a very rewarding source of biologically active natural products,
while diterpenoids from fungi, such as the cyathane-type diterpenoids from Cyathus and …

An in vitro evaluation of the molecular mechanisms of action of medical plants from the Lamiaceae family as effective sources of active compounds against human …

P Sitarek, A Merecz-Sadowska, T Śliwiński, R Zajdel… - Cancers, 2020 - mdpi.com
Simple Summary Plants have been used in folk medicine for thousands of years. The
Lamiaceae family is one of the largest families of flowering plants and includes a wide …

[HTML][HTML] Modern drug discovery applications for the identification of novel candidates for COVID-19 infections

I Rani, A Kalsi, G Kaur, P Sharma, S Gupta… - Annals of Medicine and …, 2022 - Elsevier
In early December 2019, a large pneumonia epidemic occurred in Wuhan, China. The World
Health Organization is concerned about the outbreak of another coronavirus with the …

The genus Paraconiothyrium: species concepts, biological functions, and secondary metabolites

J Wang, S Shao, C Liu, Z Song, S Liu… - Critical Reviews in …, 2021 - Taylor & Francis
The genus Paraconiothyrium has worldwide distribution with diverse host habitats and
exhibits potential utilisation as biocontrol agent, bioreactor and antibiotic producer. In this …

Esterification with a Long-Chain Fatty Acid Elevates the Exposure Toxicity of Tigliane Diterpenoids from Euphorbia fischeriana Roots against Nematodes

J Zhang, J Liu, H Li, J Hua, S Luo - Journal of Agricultural and …, 2023 - ACS Publications
In this study, two tigliane diterpenoids, 12-deoxyphorbol-13-hexadecanoate and 12-
deoxyphorbol-13-acetate (prostratin), were identified from the methanol extract of the roots …