N Vontzou, Y Pei, JC Mueller, R Reifová… - Current Opinion in …, 2023 - Elsevier
Highlights•The GRC's absence from the soma might mitigate germline-soma conflict.•Sex- specific copy number differences highlight the GRC's distorted transmission.•A …
Microbes and microbiology are seldom encountered in philosophical accounts of the life sciences. Although microbiology is a well-established science and microbes the basis of life …
Complex behavior is associated with animals with nervous systems, but decision-making and learning also occur in non-neural organisms [1], including singly nucleated cells [2–5] …
EP Hamilton, A Kapusta, PE Huvos, SL Bidwell, N Zafar… - elife, 2016 - elifesciences.org
The germline genome of the binucleated ciliate Tetrahymena thermophila undergoes programmed chromosome breakage and massive DNA elimination to generate the somatic …
J Wang, S Gao, Y Mostovoy, Y Kang… - Genome …, 2017 - genome.cshlp.org
Programmed DNA elimination is a developmentally regulated process leading to the reproducible loss of specific genomic sequences. DNA elimination occurs in unicellular …
J Wang, RE Davis - Current opinion in genetics & development, 2014 - Elsevier
Genetic information typically remains constant in all cells throughout the life cycle of most organisms. However, there are exceptions where DNA elimination is an integral …
Summary DNA N6-adenine methylation (6mA) has recently been described in diverse eukaryotes, spanning unicellular organisms to metazoa. Here, we report a DNA 6mA …
FA di Fagagna - Trends in cell biology, 2014 - cell.com
Historically, the role of cellular RNA has been subordinate and ancillary to DNA. Protein- coding mRNA conveys the information content of DNA, and transfer RNAs and ribosomal …
Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly …