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The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …

Ethylene induces anthocyanin biosynthesis in most fruits, including apple (Malus domestica)
and plum (Prunus spp.). By contrast, ethylene inhibits anthocyanin biosynthesis in pear …

The association of histone modification changes with autism spectrum disorder (ASD) has
not been systematically examined. We conducted a histone acetylome-wide association …

Adaptive thermogenesis is an important component of energy homeostasis and a metabolic
defense against obesity. We have cloned a novel transcriptional coactivator of nuclear …

Cytosine residues in the sequence 5′ CpG (cytosine–guanine) are often postsynthetically
methylated in animal genomes. CpG methylation is involved in long-term silencing of certain …

The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a
sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be …

Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent
teratogen, but its mechanisms of action in any of these settings are unknown. We report that …

More than 30 years ago, Vincent Allfrey proposed that histone acetylation was associated
with transcriptional activity in eukaryotic cells (Allfrey et al. 1964; Pogo et al. 1966) …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …