Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. refractum var. torquatum with bioactivity studies

T Kusman Saygi, N Tan, GÖ Alim Toraman… - Pharmaceutical …, 2023 - Taylor & Francis
Abstract Context The genus Glaucium Mill., one of the important Papaveraceae family
plants, is rich in isoquinoline alkaloids and distributed worldwide. Objective Isolation and …

The pharmacology, toxicology, and detoxification of Aconitum kusnezoffii Reichb., traditional and modern views

K Happy, S Yang, CH Kang, Y Kang - Applied Biological Chemistry, 2025 - Springer
Aconitum kusnezoffii Reichb. is a medicinal plant widely used in traditional Asian medicine,
especially in Korea, for its potent pharmacological effects. However, its toxic alkaloids pose …

Cholinesterase Inhibitory and In Silico Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids-Berberine as the Lead Compound

FS Senol Deniz, R Ekhteiari Salmas… - CNS & Neurological …, 2024 - ingentaconnect.com
Background: Cholinesterase (ChE) inhibitors used currently in clinics for the treatment of
Alzheimer's disease (AD) are the most prescribed drug class with nitrogen-containing …

Chelerythrine Chloride is an Affinity-Labeling Inactivator of CYP3A4 by Modification of Cysteine239

X Mao, G Zhao, Q Wang, J He, Y Liu, T Liu… - Journal of Medicinal …, 2024 - ACS Publications
Chelerythrine chloride (CHE) is a quaternary benzo [c] phenanthridine alkaloid with an
iminium group that was found to cause time-and concentration-dependent inhibition of …

Screening and Genomic Analysis of Alkaloid-Producing Endophytic Fungus Fusarium solani Strain MC503 from Macleaya cordata

X Wu, N Ibrahim, Y Liang, X Liu - Microorganisms, 2024 - mdpi.com
The extensive harvesting of Macleaya cordata, as a biomedicinal plant and a wild source of
quaternary benzo [c] phenanthridine alkaloids, has led to a rapid decline in its population …

In Vitro and In Silico of Cholinesterases Inhibition and In Vitro and In Vivo Anti-Melanoma Activity Investigations of Extracts Obtained from Selected Berberis Species

T Tuzimski, A Petruczynik, B Kaproń, T Plech… - Molecules, 2024 - mdpi.com
Berberis species have a long history of use in traditional Chinese medicine, Ayurvedic
medicine, and Western herbal medicine. The aim of this study was the quantification of the …

Potential antioxidant, α-glucosidase, butyrylcholinesterase and acetylcholinesterase inhibitory activities of major constituents isolated from Alpinia officinarum hance …

HA Al Garni, AM El-Halawany, AE Koshak… - SAR and QSAR in …, 2024 - Taylor & Francis
Alpinia officinarum is a commonly used spice with proven folk uses in various traditional
medicines. In the current study, six compounds were isolated from its rhizomes, compounds …

[HTML][HTML] Human citrate synthase kinetic simulation to fit rapid, direct, and thiol probe coupled kinetic data

N Shackelford, Z Zavodny, S Schindler… - … and Biophysics Reports, 2025 - Elsevier
Human citrate synthase (hCS) was kinetically characterized through full progress curve
kinetic modelling using kinetic simulation, global fitting of the direct AcCoA to CoA transition …

Profiling 32 alkaloid compounds from Macleaya cordata by UPLC-DAD–QTOF-MS/ms

X Zhou, Y Peng, H Zhou, W Wang, G Yi… - Natural Product …, 2024 - Taylor & Francis
Macleaya cordata is a traditional herb medicine with alkaloids as the main bioactive
substance. To identify alkaloid compounds from M. cordata, its crude extract was obtained …

Assessing Performance and Safety of Feeding a Standardized Macleaya cordata Extract to Calves

RA Matulka, J Wickramasinghe, J Dohms, FRB Ribeiro… - Animals, 2022 - mdpi.com
Simple Summary A preparation of the Macleaya cordata extract (Sangrovit®) provides a
unifying taste to feed for cattle. However, information is needed to see if the effect occurs …