Health benefits and molecular mechanisms of resveratrol: a narrative review

X Meng, J Zhou, CN Zhao, RY Gan, HB Li - Foods, 2020 - mdpi.com
Resveratrol is a bioactive compound in many foods. Since its anticancer activity was
reported in 1997, its health benefits have been intensively investigated. Resveratrol has …

The Notch signaling pathway regulates macrophage polarization in liver diseases

W Chen, Y Liu, J Chen, Y Ma, Y Song, Y Cen… - International …, 2021 - Elsevier
The liver is not only the main metabolic site of exogenous compounds and drugs, but also
an important immune organ in the human body. When a large number of nonself substances …

Comparison of physicochemical characteristics, antioxidant and immunomodulatory activities of polysaccharides from wine grapes

X Leng, J Li, W Miao, Y Liu, MS Haider, M Song… - International Journal of …, 2023 - Elsevier
In this study, an efficient ultrasonic-assisted extraction method was used for the extraction
and optimization of four wine grape polysaccharides. A three-level, three-factor Box …

Notch in fibrosis and as a target of anti-fibrotic therapy

B Hu, SH Phan - Pharmacological research, 2016 - Elsevier
The Notch pathway represents a highly conserved signaling network with essential roles in
regulation of key cellular processes and functions, many of which are critical for …

Scar management in burn injuries using drug delivery and molecular signaling: current treatments and future directions

S Amini-Nik, Y Yousuf, MG Jeschke - Advanced drug delivery reviews, 2018 - Elsevier
In recent decades, there have been tremendous improvements in burn care that have
allowed patients to survive severe burn injuries that were once fatal. However, a major …

Fibrotic events in the progression of cholestatic liver disease

H Wu, C Chen, S Ziani, LJ Nelson, MA Ávila… - Cells, 2021 - mdpi.com
Cholestatic liver diseases including primary biliary cholangitis (PBC) and primary sclerosing
cholangitis (PSC) are associated with active hepatic fibrogenesis, which can ultimately lead …

Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

J Tabeshpour, S Mehri… - Phytotherapy …, 2018 - Wiley Online Library
Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Angiocrine signaling in the hepatic sinusoids in health and disease

E Kostallari, VH Shah - American Journal of Physiology …, 2016 - journals.physiology.org
The capillary network irrigating the liver is important not only for nutrient and oxygen
delivery, but also for the signals distributed to other hepatic cell types necessary to maintain …

Notch3 regulates ferroptosis via ROS‐induced lipid peroxidation in NSCLC cells

Z Li, JY Xiao, M Liu, J Cui, B Lian, Y Sun, C Li - FEBS open bio, 2022 - Wiley Online Library
Ferroptosis is type of programmed cell death, which is known to be involved in certain
cancers. Notch3 signaling is reported to be involved in the tumorigenesis of non‐small‐cell …

Inhibition of NF-κB/TNF-α pathway may be involved in the protective effect of resveratrol against cyclophosphamide-induced multi-organ toxicity

AA El-Sheikh, MA Morsy, AM Okasha - Immunopharmacology and …, 2017 - Taylor & Francis
Abstract Context: Cyclophosphamide (CyP), an efficient anticancer drug, may damage
normal human cells. Resveratrol (RES), a natural polyphenol, has a diverse …