EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Cell-based therapies with embryonic or adult stem cells, including induced pluripotent stem
cells, have emerged as potential novel approaches for several devastating and otherwise …

Elevated C-terminal fibroblast growth factor 23 (C-FGF23) concentrations have been
reported in Gambian children with and without putative Ca-deficiency rickets. The aims of …

Coordination of differentiation and cell cycle progression represents an essential process for
embryonic development and adult tissue homeostasis. These mechanisms ultimately …

Timely cell cycle regulation is conducted by sequential activation of a family of serine-
threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves …

MicroRNAs (miRNAs) are increasingly implicated in regulating tumor malignance through
their capacity to coordinately repress expression of tumor-related genes. Here, we show that …

The cyclin-cdk (cyclin-dependent kinase) inhibitor p27 Kip1 (p27) has a crucial negative role
on cell cycle progression. In addition to its classical role as a cyclin-cdk inhibitor, it also …

Purpose: FOXA1 is a mammalian endodermal transcription factor belonging to the human
forkhead box gene family that plays a role in certain tumor types. Here, we investigated the …

p27 shifts from CDK inhibitor to oncogene when phosphorylated by PI3K effector kinases.
Here, we show that p27 is a cJun coregulator, whose assembly and chromatin association is …

Abstract p57 is a cyclin-dependent kinase (CDK) inhibitor, the first cell cycle regulator that is
regulated by imprinting. p57 was initially considered to be a tumor suppressor based on its …