Protein kinases: The key contributors in pathogenesis and treatment of nonalcoholic fatty liver disease-derived hepatocellular carcinoma

R Liu, MP Qian, YY Cui - Metabolism, 2023 - Elsevier
Protein kinases (PKs), one of the largest protein families, can be further divided into different
groups based on their substrate or structure and function. PKs are important signaling …

[HTML][HTML] Tackling ischemic reperfusion injury with the aid of stem cells and tissue engineering

M Zamorano, RL Castillo, JF Beltran, L Herrera… - Frontiers in …, 2021 - frontiersin.org
Ischemia is a severe condition in which blood supply, including oxygen (O), to organs and
tissues is interrupted and reduced. This is usually due to a clog or blockage in the arteries …

[HTML][HTML] Single-nuclei RNA sequencing assessment of the hepatic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin

R Nault, KA Fader, S Bhattacharya… - Cellular and Molecular …, 2021 - Elsevier
Background and Aims Characterization of cell specific transcriptional responses to
hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single …

[HTML][HTML] Scopoletin and umbelliferone protect hepatocytes against palmitate-and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative …

Z Wu, Y Geng, M Buist-Homan, H Moshage - Toxicology and applied …, 2022 - Elsevier
Background The number of patients with non-alcoholic fatty liver disease (NAFLD) is rapidly
increasing due to the growing epidemic of obesity. Non-alcoholic steatohepatitis (NASH) …

[HTML][HTML] NO–IL-6/10–IL-1β axis: a new pathway in steatotic and non-steatotic liver grafts from brain-dead donor rats

A Casillas-Ramírez, M Micó-Carnero… - Frontiers in …, 2023 - frontiersin.org
Introduction Brain death (BD) and steatosis are both risk factors for organ dysfunction or
failure in liver transplantation (LT) Material and methods Here, we examine the role of …

[HTML][HTML] Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia–reperfusion injury by inhibiting TAK1/JNK/p38 pathway

Q Yu, S Chen, J Li, H Tang, J Shi, W Guo, S Zhang - Scientific Reports, 2023 - nature.com
Mitogen activated protein kinase phosphatase 5 (MKP5) is a member of the MKP family and
has been implicated in diverse biological and pathological conditions. However, it is …

Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B

J Liu, X Yu, H Yu, B Liu, Z Zhang, C Kong… - Cancer Medicine, 2020 - Wiley Online Library
Mitogen‐activated protein kinase 14 (MAPK14), which plays an important role in DNA
damage and repair, is activated by various environmental stress and proinflammatory …

Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney

H Nasrallah, I Aissa, C Slim, MA Boujbiha, MA Zaouali… - Life Sciences, 2020 - Elsevier
Aims This study aimed to evaluate the effect of oleuropein (OLE), the main phenolic
compound present in olive leaves, on kidney ischemia-reperfusion injury (IRI) and to explore …

Active p38α causes macrovesicular fatty liver in mice

I Darlyuk-Saadon, C Bai, CKM Heng… - Proceedings of the …, 2021 - National Acad Sciences
One third of the western population suffers from nonalcoholic fatty liver disease (NAFLD),
which may ultimately develop into hepatocellular carcinoma (HCC). The molecular event (s) …

Inhibition of γ‐glutamyltransferase ameliorates ischaemia‐reoxygenation tissue damage in rats with hepatic steatosis

R Kubota, N Hayashi, K Kinoshita… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose Hepatic steatosis may be associated with an increased γ‐
glutamyltransferase (γ‐GT) levels. Ischaemia‐reoxygenation (IR) injury causes several …