Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in
most types of solid tumors, and were shown to facilitate cancer progression by supporting …

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

Metastatic disease is responsible for approximately 90% of cancer deaths. For successful
dissemination and metastasis, cancer cells must evade detection and destruction by the …

Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …

Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …

Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

Metastatic disease is the major cause of death from cancer, and immunotherapy and
chemotherapy have had limited success in reversing its progression. Data from mouse …