The dihydropyrimidinase-like (DPYSL) proteins, also designated as the collapsin response
mediators (CRMP) proteins, constitute a family of five cytosolic phosphoproteins abundantly …

In the last two decades, our knowledge of synaptic proteomes and their relationship to
normal brain function and neuropsychiatric disorders has been expanding rapidly through …

Genes implicated in translation control have been associated with autism spectrum
disorders (ASDs). However, some important genetic causes of autism, including the 16p11 …

The cellular mechanisms underlying axonal morphogenesis are essential to the formation of
functional neuronal networks. We previously identified the autism-linked kinase NUAK1 as a …

Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs)
are more prone to develop certain types of cancer. Notably, however, the case statistics can …

Pulmonary fibrosis (PF) is an inevitable phase of many respiratory diseases with high
mortality and limited effective treatments in the clinic. In PF, aberrant extracellular matrix …

One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes,
which may interact within shared but unknown protein complexes. Here we develop a …

Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable
treatment targets remains elusive. We constructed a foundational protein-protein interaction …

Introduction: Autism spectrum disorders (ASD) represent a heterogeneous group of
neurodevelopmental disorders with strong genetic predispositions. Although an increasing …

Thousand and one amino acid kinases (TAOKs) are relatively understudied and functionally
pleiotropic protein kinases that have emerged as important regulators of neurodevelopment …