The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling
and are essential for proper biological functions. Disruptions in this signaling axis can lead …

Lung cancer (LC) is a highly invasive malignancy and the leading cause of cancer-related
deaths, with non-small cell lung cancer (NSCLC) as its most prevalent histological subtype …

Multiple myeloma (MM) is a hematological malignancy that exhibits aberrantly high levels of
proteasome activity. While treatment with the proteasome inhibitor bortezomib substantially …

Background Hepatocellular carcinoma (HCC) is now the second leading cause of cancer
death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and …

Planarians have become an established model system to study regeneration and stem cells,
but the regulatory elements in the genome remain almost entirely undescribed. Here, by …

Multiple studies have indicated that circular RNAs (circRNAs) play a regulatory role in
different stages of tumors by interacting with various molecules. With continuous in-depth …

Ovarian cancer is a gynecological tumor with an incidence rate lower than those of other
gynecological tumor types and the second-highest death rate. CC chemokine 2 (CCL2) is a …

Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral
infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; …

Background Esophageal cancer is one of the most unknown and deadliest cancers in the
world. Although recent studies have identified some mutations linked to the development of …

Tuberculosis-induced pulmonary fibrosis (PF) is a chronic, irreversible interstitial lung
disease, which severely affects lung ventilation and air exchange, leading to respiratory …