Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …

Although obesity is one of the strongest risk factors for esophageal adenocarcinoma, the
molecular mechanisms underlying this association remain unclear. We recently identified …

Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a
high risk of induction failure and poor outcomes, with relapse due to drug resistance. Recent …

Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a
combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed …

B cell receptor associated protein 31 (BAP31) is closely associated with tumor progression,
while the role and mechanism of BAP31 in gastric cancer (GC) remains unknown. This study …

Neuroendocrine carcinoma (NEC) is a highly aggressive subtype of the neuroendocrine
tumor with an extremely poor prognosis. We have previously conducted a comprehensive …

CpG Island promoter genes make up more than half of human genes, and a subset
regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI) become DNA hypermethylated …

HNF4α, a transcription factor, plays a vital role in regulating functional genes and biological
processes. Its alternative splicing leads to various transcript variants encoding different …